Role of abnormal microRNA expression in Helicobacter pylori associated gastric cancer

Abstract

Epidemiological studies have shown that Helicobacter pylori (HP) infection is a risk factor for gastric cancer (GC). HP infection may induce the release of pro-inflammatory mediators, and abnormally increase the level of reactive oxygen species (ROS), nitric oxide (NO), and cytokines in mucosal epithelial cells of the stomach. However, the specific mechanism underlying the pathogenesis of HP-associated GC is still poorly understood. Recent studies have revealed that abnormal microRNA expression may affect the proliferation, differentiation, and apoptosis of mucosal epithelial cells of the stomach to further influence GC occurrence, development, and metastasis. Herein, we summarize the role of abnormal microRNAs in the regulation of HP-associated GC progression. Abnormal microRNA expression in HP-positive GC may be a biomarker for GC diagnosis, occurrence, and development as well as its targeted treatment and prognosis.

Keywords:

• Helicobacter pylori
• gastric cancer
• microRNA
• mechanism

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Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by National Natural Science Foundation of China under Grant (Nos. 81270036, 30901736), the Plan to Focus on Research and Development from Science and Technology project of Liaoning Province under Grant (No. 2017225029), Science and Technology Plan Project of Shenyang City under Grant (No. 18–014-4–11), and Fund for Scientific Research of The First Hospital of China Medical University under Grant (No. FHCMU-FSR).