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Critical Reviews in Toxicology Volume 51, 2021 - Issue 6
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Review Articles

Applicability of organ-on-chip systems in toxicology and pharmacology

Marlon R. Schneidera German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, GermanyORCID Iconhttps://orcid.org/0000-0002-9570-3491
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Michael Oelgeschlaegera German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, GermanyORCID Iconhttps://orcid.org/0000-0002-5787-5540
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Tanja Burgdorfa German Centre for the Protection of Laboratory Animals (Bf3R), German Federal Institute for Risk Assessment (BfR), Berlin, GermanyORCID Iconhttps://orcid.org/0000-0002-7810-5545
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Peter van Meerb Section on Pharmacology, Toxicology and Kinetics, Medicines Evaluation Board, Utrecht, The Netherlands;c Department of Pharmaceutics, Utrecht Institute of Pharmaceutical Sciences, Utrecht University, Utrecht, The NetherlandsORCID Iconhttps://orcid.org/0000-0001-6493-1697
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Peter Theunissenb Section on Pharmacology, Toxicology and Kinetics, Medicines Evaluation Board, Utrecht, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-3766-1924
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Anne S. Kienhuisd Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-6465-4498
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Aldert H. Piersmad Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The NetherlandsORCID Iconhttps://orcid.org/0000-0002-1943-7793
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Rob J. Vandebrield Laboratory for Health Protection, National Institute of Public Health and the Environment, Bilthoven, The NetherlandsCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-9140-952X
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Pages 540-554 | Received 10 Mar 2021, Accepted 30 Jun 2021, Published online: 31 Aug 2021

Figures & data

Figure 1. Example of an AOP. The MIE (in green) is linked to the AO (in red) by a series of KE (in yellow). This AOP describes the linkage between hepatic injury caused by protein alkylation and the formation of liver fibrosis. Taken from: https://aopwiki.org/aops/38.

Figure 1. Example of an AOP. The MIE (in green) is linked to the AO (in red) by a series of KE (in yellow). This AOP describes the linkage between hepatic injury caused by protein alkylation and the formation of liver fibrosis. Taken from: https://aopwiki.org/aops/38.

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