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DNA Sequence Volume 17, 2006 - Issue 1
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Original

Molecular cloning of nuclear receptor coactivator-1 gene in pig

Short communication

Dandan Yu Agriculture and Biology School, Shanghai Jiao Tong University, Department of Animal Science, Shanghai, People's Republic of China
,
He Mneg Agriculture and Biology School, Shanghai Jiao Tong University, Department of Animal Science, Shanghai, People's Republic of China
,
Chunyan Bai Agriculture and Biology School, Shanghai Jiao Tong University, Department of Animal Science, Shanghai, People's Republic of China
,
W. Zhao Agriculture and Biology School, Shanghai Jiao Tong University, Department of Animal Science, Shanghai, People's Republic of China
,
Q. S. Wang Agriculture and Biology School, Shanghai Jiao Tong University, Department of Animal Science, Shanghai, People's Republic of China
&
Yuchun Pan Agriculture and Biology School, Shanghai Jiao Tong University, Department of Animal Science, Shanghai, People's Republic of China
Pages 79-82 | Received 28 Jun 2005, Published online: 11 Jul 2009
 
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Abstract

Nuclear receptor coactivator-1 (NCOA-1) as a member of Steroid receptor coactivator (SRC) family can interact with some DNA-bound nuclear receptors and enhance their transcriptional activation function, which is physiologically and pathologically important for animals and human. Much work has been done on the gene in human and mouse, but few in pig. Here we cloned and sequenced full length cDNA of NCOA-1 gene in pig. The putative protein includes 1440 amino acids. Sequences alignment showed that pig NCOA-1 gene cDNA sequence has identity of 93.73% with human and mouse, and putative pig NCOA-1 protein has identity of 94.99% with human, mouse and rat. The motifs, LXXLL, which have been demonstrated to be important for NCOA-1 mediating ligand-dependent and direct interaction with nuclear receptor, were conserved in pig.

Notes

Foundation item: Project 30471237 supported by National Science Foundation of China. Project 2004CB117500 Supported by “973 Program” Foundation of China.

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