Abstract
The synthesis and characterization of tetracoordinated manganese (II) complexes of unsymmetrical sulpha drug azomethines having general formula (MnL 1 L 2 ) are reported. The 1:1:1 reactions of hydrated manganese chloride with unsymmetrical monobasic bidentate azomethines resulted in the formation of coloured solids. The complexes have been characterized by elemental analysis, molecular weight determinations, magnetic measurements, IR, ESR, and UV spectral studies. The magnetic and spectral studies indicate tetrahedral geometry for the resulting complexes. The ligands along with their complexes have been screened in vitro against a number of pathogenic fungal and bacterial strains. The antifertility activity of some representative ligands and their manganese complexes have been studied and important parameters like testicular biochemistry, sperm dynamics, and reproductive organ weights have been discussed. The studies indicate that the metal chelates are more potent than the parent ligands.
The authors are thankful to UGC New Delhi for financial assistance.
Notes
a Standard for antivacterial activity is streptomycin. Standard for antifungal activity is Bavistin.
a P ≤ 0.01
b P ≤ 0.001
a P ≤ 0.01.
b P ≤ 0.001.
a P ≤ 0.01.
a P ≤ 0.001.