A FACILE AND NEW METHOD FOR THE SYNTHESIS OF α-ARYL-N-METHYLNITRONES IN SOLVENT-FREE MEDIA USING SILICA GEL-NaOH

Abstract

Substituted α-aryl-N-methylnitrones are prepared by the condensation reaction of N-methylhydroxylamine hydrochloride and benzaldehydes in solvent-free media using silica-gel–NaOH catalyst system. The yields are excellent regardless of the electron-donating or electron-accepting nature of the substituents on benzaldehyde. Similar ketones are unreactive under these conditions, rendering chemoselectivity of the method.

Keywords:

• α-Aryl-N-methylnitrones
• chemoselectivity
• silica gel-NaOH
• solvent-free media