Asymmetric Synthesis Using Sulfinimines (N-Sulfinyl Imines)

Abstract

Sulfinimine-derived polyfunctionalized chiral building blocks, often prepared in one pot, provide efficient access, with a minimum of chemical manipulation, to enantiopure, multifunctional amine derivatives including piperidines and pyrrolidines.

keywords:

• Alkaloids;
• amines;
• asymmetric synthesis;
• N-sulfinylimines;
• piperidine;
• pyrrolidine

Acknowledgments

This work was supported through grants from the National Institutes of General Medicinal Sciences (GM 57870 and 51982).