Abstract
A series of 7-substituted-3-t-butyl 4(H)-1,3,4-thiadiazolo(2,3-c)-1,2,4-triazine-4-one (3) have been synthesized by condensing 4-amino-6-t-butyl-3-mercapto-1,2,4-triazin-5(4H)-one (1) with substituted Arylfuroic acids (2) using POCl3 as a cyclizing agent. The newly synthesized compounds are characterized by elemental analysis, IR, 1H NMR, and mass spectral studies. The compounds were screened for their antibacterial and antifungal activities. Some of the compounds showed promising antibacterial and antifungal activity.
Acknowledgments
The authors are thankful to IISc, Bangalore, CDRI, Lucknow, and Department of Chemistry, Mangalore University for providing NMR/Mass/IR spectra of the compounds reported. The authors are also thankful to the Government of India, Department of Science and Technology, for providing CHNS Instrument Facility under DST-FIST fund in the Department of Chemistry, Mangalore University, Mangalagangotri.