Synthesis, Characterization, and Biological Activity of Some New Benzoic Acid and Thiazoloacridine Derivatives

Abstract

A series of acridine derivatives 5have been synthesized by cylization of benzoic acid derivatives 4using POCl₃. Compounds 4 were synthesized by Ullamnn Condensation of bromo derivatives 2 and substituted anthranilic acid, respectively, which in turn have been prepared from the Schiff bases of 4-aryl-2-amino thiazole 1 and substituted aldehydes. Biological activities of all the compounds have been studied using gram positive and gram negative bacteria and their anti-fungal activity using fungal species Aspergillus Parasiticus and Sclerotium Rolfsii. All structures of the newly synthesized heterocyclic compounds were established based on elemental analyses, IR, ¹H NMR, ¹³C NMR, and mass spectra.

Keywords:

• Arylaminothiazole
• biological activity
• thiazoloacridine
• thiazoloamino benzoic acid

Acknowledgments

The authors are thankful to Dr. K C Patel and Mr. Kishor H Chauhan, Department of Biosciences, Sardar Patel University, for providing facilities for the antibacterial activity and SAIF, Punjab University, for ¹H NMR and ¹³C NMR Spectra.