Expeditious Synthesis of Thiadiazolo Benzodiazepines Under Conventional Method and Microwave Irradiation

Abstract

This article explores the use of sulfamic acid as an efficient catalyst for the one-pot synthesis of thiadiazolo 1, 5 benzodiazepines by using benzo[c][1,2,5]thiadiazole-4,5-diamine and various types of ketones in the presence of chloroform as a solvent under conventional methods and microwave irradiation. Our method is more advantageous than current methods. The catalyst (sulfamic acid) is cost effective, readily available and gives excellent yields with high purity. In comparison, the microwave irradiation method is equally as effective with a shorter reaction time and still maintaining high yields.

Keywords:

• Benzodiazepine; benzo[c][1,2,5]thiadiazole-4,5-diamine
• ketone
• sulfamic acid

Financial assistance from U.G.C (RGNF) Grant No: F.16-158/2006(SA-II) New Delhi is gratefully acknowledged.