Synthesis and Anti-Inflammatory Activities of Some Novel S-Pyridyl Glycosides Derivatives

Abstract

A series of some new acetylated S-glycosides of pyridine-2-thione derivatives, including D-glucose, D-galactose, D-xylose and L-arabinose derivatives were synthesized. Oxidation of some formed S-glycosides derivatives with H₂O₂ afforded the corresponding sulfones. S-Alkylation of pyridine-2-thione derivatives was performed to furnish the S-acyclo deazauridine derivatives. The entire tested compound showed potent anti-inflammatory activity were potent against edema and in the same time inhibited the prostaglandine formation. It is work mention that all the tested compounds showed high safety margin. The structures of the new synthesized compounds have been proved by IR, ¹ HNMR, mass spectra and elemental analysis.

Keywords:

• Anti-inflammatory activity
• glycoside derivatives
• 5,6,7,8-Tetrahydronaphthalene

Notes

∗The doses tested were 25, 50 mg and carryout three determinations for each dose.

∗The doses tested were 25, 50 mg and carryout three determinations for each dose.