Mild and Ecofriendly Tandem Synthesis, and Spectral and Antimicrobial Studies of N¹-Acetyl-5-aryl-3-(substituted styryl)pyrazolines

Abstract

N¹-acetyl-5-aryl-3-(substituted styryl)pyrazolines were synthesized by the cyclocondensation of 1,5-substituted diphenyl-1,4-pentadien-3-ones with hydrazine hydrate and a cyclizing agent such as acetic acid in ethanol. The title compounds were synthesized using conventional and solvent-free approaches, which involves mechano-chemical mixing, microwave-irradiation, and ultrasound-irradiation methods in the presence of a solid support. The synthesized compounds have been characterized by elemental analyses and spectral data (IR, PMR, and FAB-mass). All the synthesized compounds have been evaluated for their antibacterial and antifungal activities. Some compounds have shown promising biological activity.

Keywords:

• Bischalcones
• microwave-irradiation
• pyrazolines
• ultrasound-irradiation

We express our sincere gratitude to Dr. K. P. Madhusunan, Deputy Director and Head, SAIF, Central Drug Research Institute (CDRI), Lucknow, India, for elemental analyses and spectral (IR, NMR, and FAB Mass) data. The authors are thankful to the coordinator of the Centre of Advanced Studies, Department of Chemistry, for providing chemicals. One of the authors (R. J.) is thankful to UGC, New Delhi, for financial support.