Synthetic Methodology, Spectral Elucidation, and Antioxidative Properties of Benzothianes and Their Sulfones

Abstract

This article reflects the synthetic strategies and spectral investigation of 4H-1,4-benzothiazines. 4H-1,4-benzothiazines have been prepared by the condensation and oxidative cyclization of substituted 2-aminobenzenethiol with β-diketones/β-ketoesters in dimethyl sulfoxide and with the oxidation of 4H-1,4-benzothiazines by 30% hydrogen peroxide in glacial acetic acid, which results in the formation of 4H-1,4-benzothiazine sulfones. The compounds were evaluated for their antioxidative properties through in vitro and in vivo studies in Swiss albino mice. The structural assignments of compounds were made on the basis of spectroscopic data and elemental analysis.

Keywords:

• Antioxidant activities
• benzothiazines
• sulfones
• Swiss albino mice

Authors are thankful to the Head, Chemistry and Zoology Department, University of Rajasthan, Jaipur, India for laboratory facilities. Thanks are due to CSIR and UGC (Bhopal) for financial support. Thanks are also due to CDRI, Lucknow for providing the IR, proton NMR, and mass facilities.