Thio Analogues of Pyrimidine Bases: Syntheses and Spectral Study of New Potentially Biologically Active 2,4-Di-Ortho-(Meta- and Para-)Bromo- (Chloro and Nitro)-Benzylthio-5-Bromouracils (and 6-Methyluracils)

Abstract

Eighteen new 2,4-di-ortho- (meta- and para-) bromo-(chloro- and nitro-)benzylthio-5-bromouracils (and 6-methyluracils) have been prepared. The structures of these compounds were confirmed by spectral (IR, UV/vis, ¹H NMR) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of prediction of activity spectra for substances (PASS).

Keywords:

• 2,4-Dibenzylthio-5-bromo-6-methyluracils
• 2,4-dibenzylthio-5-bromouracils
• ¹H NMR
• IR
• PASS
• structural isomers
• UV/vis

Notes

*Solvent: CHCl₃-CH₃OH, 5:1.