Microwave-Induced Synthesis and Bioactivity of [3-Phenoxy-methyl-4-phenyl-1,2,4-triazole-5-yl-thio]acetyl Hydrazone Derivatives

Abstract

A convenient method for the preparation of hydrazone derivatives from condensation reaction of [3-phenoxymethyl-4-phenyl-1,2,4-triazole-5-yl-thio]acetyl hydrazine with various substituted benzaldehydes under conditions of microwave irradiation has been developed. This method has many merits including high yields, short reaction times, ease of work-up, and simple operation. All of the compounds have been characterized by ¹H NMR, ¹³C NMR, IR spectra and elemental analysis. In addition, the preliminary biological activity tests showed that some of the title compounds remarkably enhanced the root elongation of rape seedings; moreover, some compounds possessed antibacterial activity against Bacillus subtilis.

Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

Keywords:

• Antibacterial activity
• biological activity
• hydrazone
• triazole

Acknowledgments

This work was supported by the NSFC (No. 20671077) and the Natural Science Foundation of Gansu (2008-1-164), which are gratefully acknowledged.