Synthesis and Antioxidant Properties of Novel 1,3,2-Oxazaphospholanes Incorporating 1,2-Dihydropyridines

Abstract

Novel chiral 1,3,2-oxazaphospholane-2-sulfides incorporating a dihydropyridine ring have been synthesized via phosphorylation of 2-aminopyridinium salts, followed by in situ oxidation and cyclocondensation with 2-(alkylamino)ethanol. Cyclic organothiophosphates thus obtained have been screened for their antioxidant properties.

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Keywords:

• Antioxidant property
• 1,2-dihydropyridine
• 1,3,2-oxazaphospha heterocycles
• phospholane ring system

Acknowledgments

We are highly grateful to the UGC, New Delhi, India, for financial assistance; CDRI, Lucknow, India, for mass spectra; and the Department of Chemistry, University of Rajasthan, for providing necessary facilities.