Synthesis of Phosphonoindoprofen

Abstract

Two synthetic routes to phosphonic analogues of indoprofen, a nonsteroidal anti-inflammatory drug, were developed by the cyclization of aniline 2 (method A) and by the Arbuzov reaction of corresponding alkylchloride 3 with triethylphosphite (method B).

Keywords:

• Indoprofen
• isoindolin-1-ones
• phosphonic acids

Acknowledgments

This work was supported by the STCU grant no. 3558.

Notes

*According to ¹Н NMR spectra.