SnCl₂·2H₂O: An Efficient Reagent for Selective and Direct Oxidative Desulfurization of Phenylmethylene-2-thiohydantoins to Corresponding Hydantoins

Abstract

A new and efficient protocol is presented for selective and direct oxidative conversion of phenylmethylene-2-thiohydantoins to corresponding hydantoins. It involves the use of SnCl₂.2H₂O, which oxidatively desulfurizes the phenylmethylene-2-thiohydantoins to their corresponding hydantoin analogues in good to excellent yields while all other 2-thiohydantoins remain unaffected.

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GRAPHICAL ABSTRACT

Keywords:

• Hydantoin
• oxidative desulfurization
• phenylmethylene-2-thiohydantoins
• SnCl₂.2H₂O

Acknowledgments

We acknowledge SAIF, CDRI, for providing analytical data. R.K. and S.P. thank the Council of Scientific and Industrial Research, India, for Senior and Junior Research Fellowships, respectively. S.K. thanks UGC New Delhi, India, for a Junior Research Fellowship. CDRI Communication No. 7906.