Design and Synthesis of Thiazole and Thiazolidine Metallo-Supramolecular Networks

Abstract

A mild and selective procedure for the synthesis of 4-carboxy thiazoles and thiazolidines starting from naturally occurring cysteine by condensation with aldehydes is described. The optimized procedure, taking advantage of the positive effect of microwave irradiation on the MnO₂-mediated oxidation step, is suitable for multigram scale. Coordination of these ligands towards a variety of transition metal ions gave new interesting metallorganic supramolecular architectures in which an extensive 3D network is created through hydrogen bonding.

Keywords:

• Amino acid
• coordination complexes
• thiazoles
• thiazolidines

Acknowledgments

The authors thank Ente Cassa di Risparmio–Firenze through the motu proprio FIRENZE HYDROLAB project (www.iccom.cnr.it/hydrolab/) for supporting this research activity.