One-Pot Three-Component Synthesis of 3-Methyl-4-Arylmethylene- Isoxazol-5(4H)- Ones Catalyzed by Sodium Sulfide

Abstract

3-Methyl-4-arylmethylene-isoxazol-5(4H)-ones were synthesized by the convenient three-component reaction of ethyl acetoacetate, hydroxylamine hydrochloride, and aromatic aldehydes catalyzed by sodium sulfide in the presence of ethanol at room temperature. The advantages of this procedure were mild reaction conditions, high yields, short reaction time, and operational simplicity.

GRAPHICAL ABSTRACT

Keywords:

• Sodium sulfide
• 3-methyl-4-arylmethylene-isoxazol-5(4H)-ones
• one-pot synthesis

Acknowledgments

We gratefully thank Taishan University for the financial support.