Abstract
Saccharin sulfonic acid (SaSA) is used as a highly efficient and recyclable catalyst for the one-pot multicomponent condensation of 2-naphthol with arylaldehydes and amides (thioamides or alkyl carbamates) under green, mild (70 °C), and solvent-free conditions. In this reaction, 1-amidoalkyl-2-naphthols, 1-thioamidoalkyl-2-naphthols, 1-carbamatoalkyl-2-naphthols, bis(1-amidoalkyl-2-naphthol)s, and bis(1-carbamatoalkyl-2-naphthol)s are produced in high to excellent yields and in relatively short reaction times.
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GRAPHICAL ABSTRACT
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Acknowledgments
The authors gratefully acknowledge support of this work by the Research Affairs Office of Payame Noor University, Bu-Ali Sina University (Grant number 32–1716 entitled development of chemical methods, reagents and molecules), and Persian Gulf University, and also Center of Excellence in Development of Chemical Method (CEDCM), Hamedan, Iran.