Synthesis and Antibacterial and Antifungal Properties of Novel S-, N-, N,S-, and S,O-Substituted 1,4-Naphthoquinone Derivatives

Abstract

A novel series of substituted 1,4-naphthoquinone derivatives were synthesized and evaluated for their antibacterial and antifungal activity. The structures of the novel products were characterized by spectroscopic methods. Among the tested compounds, 2,2′,3,3′-alkoxy substituted naphthoquinones, S,O-substituted naphthoquinone, and N,S-substituted naphthoquinone derivatives are the most potent antifungals against C. tenuis. 2,3-Thio-2′,3′-alkoxy substituted naphthoquinones are the most effective antifungal compounds against A. niger.

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GRAPHICAL ABSTRACT

Keywords:

• N,S-substituted 1,4-naphthoquinones
• heterocyclic ethers with quinone group
• antibacterial activity
• antifungal activity

Acknowledgments

Financial support from TUBITAK for the Ukraine-Turkey agreement (Project No. 109T617) and from the State Agency on Science, Innovations and Informatization of the Ukraine (Project No. M/309-2011) is gratefully acknowledged.