New 2H-Azirin-3-Amines as Synthons for Sulfur-Heterocyclic α-Amino Acids

Abstract

Three new spiroheterocyclic 2H-azirin-3-amines, which contain a sulfur atom, were prepared and successfully used for the synthesis of oligopeptides containing sulfur-heterocyclic α-amino acids via the “azirine/oxazolone method.”

GRAPHICAL ABSTRACT

Keywords:

• 2H-Azirin-3-amines
• Spirothiaheterocycles
• Heterocyclic alpha-amino acids

Acknowledgments

Financial support of our research project by the Swiss National Science Foundation and F. Hoffmann-La Roche AG, Basel, is gratefully acknowledged.