Synthesis of New 1,2,4-Triazole-5-Thiones and Their Thioglycoside Derivatives as Potential Antibacterial Agents

Abstract

Abstract The glycosylation of 1,2,4-triazole-5-thiones has been performed with peracetylated β-pyranosyl bromide in the presence of potassium carbonate. The synthesized compounds were tested for their antimicrobial activity against bacterial (Gram-negative and Gram-positive) and yeasts strains in vitro. The synthetic compounds showed different inhibition zones against tested bacterial and yeasts strains. Among them, compounds which possessed 2-furyl and p-bromophenyl moieties showed the best results against Acinetobacter calcoaceticus ATCC 23055.

GRAPHICAL ABSTRACT

Keywords:

• 1,2,4-Triazole-thione
• β-pyranosyl
• thioglycoside
• antimicrobial
• yeasts strain
• in vitro

Acknowledgments

We gratefully acknowledge the University of Urmia for providing a fellowship to us for the present work (project no: 008/E/90).