Abstract
Various 2-thioxo and 2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carbonitriles were synthesized in very high yields in 40 min through a direct condensation of an equimolar amount of an aldehyde, malononitrile, and thiourea/urea under ball mill solvent-free and catalyst-free conditions.
GRAPHICAL ABSTRACT
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Acknowledgments
The authors are very much thankful to King Abdulaziz City for Science and Technology (KACST) and King Saud University (KSU) for recording the analysis of synthesized compounds.