Green and Efficient Method for Thiocyanation of Aromatic and Heteroaromatic Compounds Using Cross-linked Poly (4-Vinylpyridine) Supported Thiocyanate Ion as Versatile Reagent and Oxone as Mild Oxidant

GRAPHICAL ABSTRACT

Abstract

A green and efficient regioselective thiocyanation of indoles, anilines and pyrrole has been achieved via a simple protocol using cross-linked poly (4-vinylpyridine) supported thiocyanate ion, [P₄-VP]SCN, as a versatile polymeric reagent and oxone as an environmentally friendly and mild oxidant. Various indoles, anilines, pyrroles, and carbazoles were transformed into their corresponding aryl thiocyanates in high to excellent yields in a short reaction time. The present procedure offers advantages such as simple reaction work-up, and the polymeric reagents can also be regenerated and reused several times without significant loss of their activity.

Keywords:

• Thiocyanation
• oxone
• regioselectivity
• polymeric reagent
• aryl thiocyanate