GRAPHICAL ABSTRACT
Abstract
A series of carbazole-based thiazole derivatives were synthesized and characterized. The title compounds were evaluated for their cytotoxicity against three cancer cell lines A549, MCF-7, and HT29 by MTT assay. Among several thiazole derivatives, compounds 4-(4-bromophenyl)-2-(2-((9-ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)thiazole (3f) and 2-(2-((9-ethyl-9H-carbazol-3-yl)methylene)hydrazinyl)-4-(4-nitrophenyl)thiazole (3g) are found to display significant cytotoxicity against three cancer cell lines. These compounds have also been tested for antioxidant activity and are found to exhibit higher antioxidant activity than that of the standard BHT.