Synthesis of α-Aminophosphonate Derivatives by Microwave-Assisted Kabachnik–Fields Reaction

GRAPHICAL ABSTRACT

Abstract

The synthesis of aminophosphonates was studied in aqueous solution using triethyl phosphite and under solvent-free and microwave-assisted conditions using >P(O)H species and starting from primary amines or α-, β- and γ-amino acid derivatives. The synthesis of bisaminophosphonates from suitable bifunctional compounds was also investigated in the presence of the T3P reagent.

Keywords:

• Kabachnik–Fields reaction
• microwave
• α-aminophosphonate
• ring platinum complex