Addition of dimethyl phosphite to N,N'-dialkyl- and -diaryl terephthalaldimines and its stereochemistry contrary to behavior of other analogues

GRAPHICAL ABSTRACT

ABSTRACT

The addition of dimethyl phosphite to N,N'-terephthalylidene-alkyl- (or aryl-) amines resulted in new tetramethyl 1,4-phenylene-bis-(N-alkylaminomethyl)-phosphonates in moderate yields. The stereochemical behavior of these reactions was studied by NMR, demonstrating that the reactions lead to the formation of both possible diastereomeric forms from 1:1 to 1:2 ratios. This was unexpected considering that previously investigated additions of diethyl, dibenzyl, and diphenyl phosphites to terephthalaldimines were diastereoselective up to 100%. Attempts were made to find reasonable explanation for the phenomenon using semi-empirical and DFT calculations.

KEYWORDS:

• Diaminophosphonates
• terephthalic moiety
• stereochemistry
• dimethyl phosphite

Funding

Small financial support of the Faculty of Chemistry, University of Łódź is kindly acknowledged. Quantum calculations were supported in part by PL-Grid Infrastructure.