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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 192, 2017 - Issue 1
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Original Articles

Synthesis, characterization, antimicrobial activities, and QSAR studies of organotin(IV) complexes

Rajesh MalhotraDepartment of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, IndiaCorrespondence[email protected]
,
Ankit RaveshDepartment of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
&
Vikramjeet SinghDepartment of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, Haryana, India
Page 0 | Received 16 May 2016, Accepted 12 Aug 2016, Published online: 04 Nov 2016
 
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ABSTRACT

Organotin complexes of type R2SnClL [where L = Schiff base obtained by the condensation of 2-(4-Bromo/Chloro-benzyloxy)-3-methoxy-benzaldehyde and nicotinic/isonicotinic hydrazides; R = Me, Et, Bu, and Ph] have been synthesized and characterized by elemental analysis, molar conductance, infrared and NMR (1H, 13C, and 119Sn) spectral analyses. The ligands and their organotin complexes have been evaluated for antimicrobial activity and the QSAR studies indicated that antimicrobial activity of target compounds is governed by total energy of molecule and topological descriptors.

GRAPHICAL ABSTRACT

Funding

Ankit Ravesh is grateful to the Council of Scientific and Industrial Research (CSIR) New Delhi for the financial support to the research.

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