ABSTRACT
The latest achievements in the synthesis of aromatic and heteroaromatic pentafluorosulfanyl-substituted compounds by nucleophilic substitution approach are summarized. The effect of the SF5 group on relative reactivities in a model vicarious nucleophilic substitution (VNS) is reported. The pentafluorosulfanyl group was found to activate nitrobenzenes for VNS more strongly than trifluoromethyl or cyano groups.
Funding
Financial support from the Academy of Sciences of the Czech Republic (Research Plan RVO: 61388963) is gratefully acknowledged.