ABSTRACT
A series of new biologically active phenyl N,N′-phenyl phosphorodiamidates were synthesized by reacting phenyl phenylphosphoramidochoridate with various amines. All the newly synthesized compounds 3a-j were tested for their antioxidant activity by 1,1-diphenyl-2-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2) and nitric oxide (NO) methods. In all the three methods the compounds 3c (phenyl N-(6-methoxy-1,3-benzothiazol-2-yl)-N′-phenyl-phosphorodiamidate) and 3e (phenyl N-(5-ethyl-1,3,4-thiadiazol-2-yl)-N′-phenylphosphorodiamidate) showed good radical scavenging activity.
Acknowledgments
The authors express their grateful thanks to SAIF, IIT, Chennai and Hyderabad Central University for providing instrumentation facilities for recording the spectra and elemental analyses.