Achievements in developments of organophosphorus stereochemistry

Abstract

This communication is devoted to the theoretical and synthetic aspects of the stereochemistry of organophosphorus compounds. The nature of the chirality generation in the prebiotic period, the mechanisms of asymmetric induction, and double stereodifferentiation are discussed. The use of these methods for the preparation of chiral phosphorus analogs of natural compounds (phosphono-isonorstatin, phosphono-GABOB, phosphacarnitine, bis-phosphonates, and others) is described. Some data concerning of λ⁵-phosphanediones as metaphosphate anion analogues were also reported.

Graphical Abstract

Keywords:

• Stereochemistry
• asymmetric induction
• double stereodifferentiation
• chiral bis-phosphonates
• phosphono-isonorstatin
• λ⁵-phosphanedione

Disclosure Statement

No potential conflict of interest was reported by the authors.