Vinyl fluorosulfonamide: a practical vinyl electrophilic reagent for mild and efficient synthesis of ketones under catalyst- and additive-free conditions

Abstract

A catalyst- and additive-free hydrolysis of alkenyl fluorosulfonamides is achieved, providing an efficient approach for the synthesis of various aryl ketones in moderate to excellent yields. This reaction exhibits broad functional group compatibility without the formation of undesired desulfonation compounds. Moreover, the procedure operates under the mild conditions avoiding the use of additional metal catalysts or potential security risk substrate (vinyl azide), and the reaction finishes in short reaction time (30 min) at room temperate.

Graphical Abstract

Keywords:

• Catalyst-free
• hydrolysis
• fluorosulfonamide
• ketone
• enamine

Disclosure statement

There is no conflict of interest to report.

Additional information

Funding

The financial support from the National Natural Science Foundation of China (Nos: 22078192, 81973453), and Program of Innovative Research Team of Shanghai University of Engineering Science (Nos: 20KY0420, 20KY0426) are gratefully acknowledged.