An ultra-sound assisted synthesis of α-aminophosphonates from benzyl halides via sequential Kornblum and Kabachnik-fields reaction

Abstract

An ultrasound-assisted simple, easy and straightforward method for the synthesis of α-aminophosphonates has been developed via Kornblum/Kabachnik-fields reaction. The method involves in situ generation of an aldehyde intermediate from benzyl halides via oxidative dehalogenation followed by coupling with aryl amine and trialkyl phosphite in a one-pot three component manner under ultrasonic irradiations. The developed method is compatible with various functionalities and the desired products are obtained in good to excellent yield under mild conditions.

Graphical Abstract

Keywords:

• Benzyl halides
• ultrasonication
• one-pot synthesis
• aminophosphonates

Acknowledgements

This research was partly supported by a grant from the CSIR under scheme No 02(0457)/21/EMR-II.

Disclosure statement

The authors declare that there is no conflict of interest.