Synthesis of Polyfunctionally Substituted Thiophene, Thieno[2,3-b]pyridine and Thieno[2,3-d]pyrimidine Derivatives

The thiophne derivatives 4a–c were prepared according to the Gewald procedure. Their reactivity towards a variety of chemical reagents was studied to give thienopyridines and pyrimidines. Biological investigations were carried on the newly synthesized products.

KEYWORDS:

• Bactericidal
• fungicidal
• thieno[2,3-d]pyrimidine
• thienopyridine[2,3-b]pyridine
• thiophene

Notes

^a Slight inhibition, +; moderate inhibition, ++; Strong inhibition, +++; rating percent control: no inhibition, 0; slight inhibition, 10, 20, 30; moderate inhibition, 40, 50, 60; strong inhibition, 70, 80, 90; complete inhibition, 100.