Synthesis of New Porphyrin-Containing Peptidyl Phosphonates

Synthesis of new, porphyrin-containing peptidyl aminophosphonates is described. The products, derived from 5-(4′-carboxyphenyl)-10,15,20-tri-p-tolylporphyrin and some heterocyclic aminophosphonates were obtained in high yield in the reaction of the 5-(4′-carboxyphenyl)-10,15,20-tritolylporphyrin with selected thiophene and pyridine aminophosphonate diphenyl esters by applying a DCC coupling method used in the peptide synthesis. The obtained porphyrin aminophosphonate products were characterized by spectroscopic methods.

Keywords:

• Aminophosphonate derivatives of 5-(4′-carboxyphenyl)-10, 15,20-tri-p-tolyl-porphyrin
• peptide synthesis
• porphyrins
• tolylporphyrins

Acknowledgments

This work was supported by the Institute of Chemistry, University of Silesia, Katowice, Poland.