Synthesis, Antimicrobial Activity, and ⁷⁷Se NMR of Some New Pyrrole Derivatives Containing a Diphenyl Selenide Moiety

A simple and mild synthesis for pyrrolyl and pyrrolo[2, 3]pyrimidinyl diphenyl selenides is described based on the reaction of active methylene compounds with 4′-nitro-4-acetylaminodiphenyl selenide. The sensitivity of ⁷⁷Se NMR spectra allowed differentiating the rather similar pyrrole compounds. The synthesized compounds were screened for their antifungal and antibacterial activities.

Keywords:

• ⁷⁷Se NMR
• antibacterial activity
• antifungal activity
• diphenyl selenide
• keto enol tautomers
• pyrrole

Notes

*Reference compounds: Chloramphenicol 5% (bacteria), Terbinafine 5% (fungi).