The prognostic value of toll-like receptor5 and programmed cell death-ligand1 in patients with peripheral T-cell non-Hodgkin lymphoma

Abstract

TLR5 is expressed in a variety of tumors. However, the clinical impact of TLR5 in Peripheral T-cell non-Hodgkin lymphomas (PTCLs) remains unclear. We analyzed differentially expressed genes in PTCLs samples from Gene Expression Omnibus database. We examined TLR5 and programed cell death-ligand1 (PD-L1) expression by immunohistochemistry in PTCLs tissues. Gene expression profiling shown PD-L1 and TLR5 expression was higher in PTCLs than in normal samples. The rates of high TLR5 and PD-L1 expression were 12.5% and 45.8%. We found association between TLR5 and PD-L1 expression. Low TLR5 expression or high PD-L1 expression was correlated with shorter overall survival and inferior disease-free survival. Multivariate Cox regression analysis shown low TLR5 expression, high PD-L1 expression, gender, and high IPI score were prognostic factors (p < .05). PTCLs patients with low TLR5 expression and high PD-L1 expression had worse prognosis. TLR5 and PD-L1 may serve as potential therapeutic targets in PTCLs patients.

Keywords:

• Peripheral T-cell non-Hodgkin lymphomas (PTCLs)
• TLR5
• PD-L1
• cancer prognosis

Acknowledgments

This experiment was finished in the oncobiology key lab of the Heilongjiang Province common institution of higher learning.

Ethical approval

All procedures performed involving human participants in our study were in accordance with the ethical standards of the Institutional and/or research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Potential conflict of interest

Disclosure forms provided by the authors are available with the full text of this article online at https://doi.org/10.1080/10428194.2019.1602266.

Additional information

Funding

The study was supported by the Natural Science Foundation of Heilongjiang Province [No. H2018045], University of Texas MD Anderson Cancer Center Sister Institution Network Fund and Heilongjiang Provincial Returned Scholars Science Fund [No. LC2015035].