Glucocorticoid receptor expression in multiple myeloma patients is a predictor of survival

Figures & data

Table 1. Variables significantly associated with survival for all patients.

Variable	Est	SE	RR	p^a
6p22	–0.71	0.31	0.49	0.02
Albumin	–0.06	0.02	0.95	0
NR3C1 FPKM	–0.04	0.01	0.96	0
Age	0.04	0.01	1.04	0
6q25	0.59	0.25	1.8	0.02
1q21	0.61	0.21	1.85	0
8q24	0.85	0.29	2.34	0
17q23	1.13	0.36	3.09	0
t(14;16)	1.2	0.54	3.33	0.02
5p15	1.45	0.47	4.26	0
t(14;20)	1.86	0.56	6.42	0

a Chromosomal aberrations, all gains except for 6q25 (deletion), are categorical variables; rest is continuous. Est.: Cox model coefficient estimate; SE: standard error; RR: relative risk = exp(Est), p: p-value; SCT; stem cell transplant.

Table 2. Variables significantly associated with survival stratified by stem cell transplantation.

	Variable	Est.	SE	RR	p^a
SCT-	Albumin	–0.05	0.02	0.95	0.00
	NR3C1 FPKM	–0.03	0.01	0.97	0.00
	1q21	0.51	0.21	1.67	0.02
	8q24	0.67	0.26	1.96	0.01
	6q25	0.68	0.24	1.98	0.00
	t(14;16)	1.27	0.63	3.58	0.04
	t(14;20)	1.60	0.63	4.93	0.01
SCT+	6p22	–1.71	0.65	0.18	0.01
	NR3C1 FPKM	–0.04	0.01	0.96	0.00
	1q21	0.98	0.36	2.66	0.01
	6q25	1.06	0.44	2.88	0.02
	t(14;16)	1.40	0.64	4.07	0.03
	t(14;20)	2.38	0.83	10.83	0.00

a Chromosomal aberrations, all gains except for 6q25 (deletion), are categorical variables; rest is continuous. Est.: Cox model coefficient estimate; SE: standard error; RR: relative risk = exp(Est); p: p-value; SCT: stem cell transplant.

Figure 1. Survival characteristics of the SCT– (left panel) and SCT+ (right panel) patients. Upper row: K–M curves, bottom row: distribution of NR3C1 expression values. Quartiles Q1 and Q3 are marked as vertical lines.

Figure 2. Effect of translocations t(14:20) and t(14:16) on NR3C1 expression for all patients.

Table 3. Variables significantly associated NR3C1expression (linear model).

Variable	Coeff.	SE	p^a
t(14;20)	40.40	5.58	0.00
t(14;16)	37.21	3.80	0.00
2q22	8.70	3.96	0.03
6q25	7.78	1.82	0.00
13q34	5.90	2.79	0.03
16q22	3.77	1.74	0.03
t(4;14)	–6.51	2.69	0.02
t(8;14)	–7.32	1.99	0.00
9q33	–7.53	3.43	0.03
Const	99.96	32.20	0.00

a Coeff: linear model coefficient; SE: standard error; p: p-value. Chromosomal aberrations 2q22, 9q33 are gains and 13q34, 16q22 are deletions.