Polyurethane foam dressings ameliorating local adverse effects of azacitidine: a randomized controlled trial

Figures & data

Table 1. Comparison of baseline data between the experimental group and the control group.

Variable	Experimental group (N = 55)	Control group (N = 55)	t/z/X^2	p value
Sex			0.34^a	0.55
Male	32	35
Female	23	20
Age	51 ± 14.9	53 ± 18.3	0.63^b	0.53
BMI	22.6 ± 2.7	22.9 ± 2.6	−0.56^b	0.55
Disease type			0.04^a	0.85
AML	33	34
MDS	22	21

^aX² value; ^bT value. AML: acute myeloid leukemia; BMI: body mass index; MDS: myelodysplastic syndrome.

Table 2. Comparison of pain at the subcutaneous injection site of azacitidine between the experimental group and control group (N).

Variable	Experimental group (N = 55)	Control group (N = 55)	Test statistic	p value
Peak pain score	2.1 ± 1.2	4.5 ± 2.0	7.631^a	<0.001
Low pain score	1.6 ± 1.1	3.1 ± 1.4	−6.248^a	<0.001
Duration of pain (d)	2.3 ± 1.1	4.6 ± 1.9	−7.769^a	<0.001
Time of peak pain			−^b	0.800
First day	15	12
Second day	23	28
Third day	10	8
Fourth day	3	5
Fifth day	3	2
Sixth day	1	0
Seventh day	0	0

^aIs a t-test, and the test statistic is T; ^bis a chi-square test, and the test statistics are continuously corrected chi-square values.

Table 3. Comparison of local adverse reactions at the injection site between the experimental group and control group.

Variable	Experimental group (N = 55)	Control group (N = 55)	Test statistic	p value
Degree of local adverse reactions			27.080^a	<0.001
None	30 (54.4)	8 (14.5)
Mild	19 (34.5)	19 (34.5)
Moderate	4 (7.3)	16 (29.1)
Severe	2 (3.6)	12 (21.8)
Time of the most serious local adverse reaction			−^b	0.013
First day	2	3
Second day	15	12
Third day	4	25
Fourth day	3	5
Fifth day	1	2
Sixth day	0	0
Seventh day	0	0
Duration of local adverse reaction (d)	2.9 ± 1.5	5.2 ± 1.6	−7.777^c	<0.001

^aIs a chi-square test, and the test statistic is χ²; ^bis a chi-square test, and the test statistics are continuously corrected chi-square values; ^cis a t-test, and the test statistic is T.