Acknowledgements
The authors would like to thank the patients who took part in the study and their families, as well as the staff, research coordinators, and investigators at each participating institution. We gratefully acknowledge the support of the CoCo Neurosciences study group and the LOC network.
Ethical approval
The study was conducted in compliance with the Declaration of Helsinki. Approval was obtained from the local ethics committee (IRB approval 2020CER-202028).
Author contributions
AL, CH and KHX designed the study. AL, CH, RU, ET, VH, GA, SC, CS, CMC, BM, KM, VP, LN, SM and MT collected the data. AL and CH reviewed and analyzed the clinical data. AL and CH wrote the initial draft, with input from all authors. All authors participated in data analysis, reviewed and approved the final manuscript.
Disclosure statement
All authors report no disclosures relevant to the manuscript. MT has a consulting or advisory role with Agios Pharmaceutical, Integragen, and Taiho Oncology, and research funding from Sanofi.