Precision and strategic targeting of novel mutation-specific vulnerabilities in acute myeloid leukemia: the semi-centennial of 7 + 3

Figures & data

Figure 1. Functional genomic clusters in AML, organized alphabetically by known recurrently mutated genes. Width of chords in the circos plot do not correspond to frequency of aberrations.

Figure 2. Summary of mutation-specific vulnerabilities and molecular dependencies in the experimental or pharmacologic pipeline for AML. Phase of experimentation for each therapeutic is included, ranging from pre-clinical through FDA approval.

Data availability statement

There was no new data generated.