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Journal of Herbs, Spices & Medicinal Plants Volume 20, 2014 - Issue 4
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Original Articles

Anti-inflammatory and Anti-proliferative Properties of Chromolaena odorata Leaf Extracts in Normal and Skin-Cancer Cell Lines

Varma N. G. YajarlaSchool of Life Sciences, University of Hyderabad, Hyderabad, India
,
Reddy P. NimmanapalliSchool of Life Sciences, University of Hyderabad, Hyderabad, India
,
Sridevi ParikapandlaSchool of Life Sciences, University of Hyderabad, Hyderabad, India
,
Geetika GuptaSchool of Life Sciences, University of Hyderabad, Hyderabad, India
&
Roy KarnatiSchool of Life Sciences, University of Hyderabad, Hyderabad, IndiaCorrespondence[email protected]
Pages 359-371 | Received 26 Aug 2013, Published online: 02 May 2014
 
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Abstract

Leaf extracts of Chromolaena odorata were evaluated for anti-inflammatory and anti-proliferative activities in normal and cancerous skin cell lines. Ethyl acetate extract was high in phenolic, flavonoid contents and exhibited antioxidant and free radical scavenging capacity. A dose-dependent decrease in LPS-induced TNF-α and IL-1β was observed in HaCaT cells treated with ethyl acetate extract. Hexane and ethyl acetate extracts showed cytotoxicity and arrest of A431 cells in sub-G1 phase.

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