Surveillance of Diversion and Nonmedical Use of Extended-Release Prescription Amphetamine and Oral Methylphenidate in the United States

Figures & data

TABLE 1 Extended-Release Amphetamine and Oral Methyl- phenidate Prescription Products in IMS NPA

Extended-release	Extended-release oral
amphetamine^†	methylphenidate^†
Adderall XR (Shire)	Concerta (Ortho McNeil Janssen)
Generic Amphetamine Salts ER	Focalin XR (Novartis)
Dexedrine Spansule (GlaxoSmithKline)	Metadate CD (UCB Inc.)
Vyvanse (Shire)	Metadate ER (UCB Inc.)
	Methylin ER (Mallinckrodt)
	Generic Methylphenidate LA
	Ritalin-SR (Novartis)
	Ritalin LA (Novartis)
† The listed products are United States trade names and may not be available in other countries. Formulations vary among products.

FIGURE 1 ADHD prescribing information for ER amphetamine^a and ER oral methylphenidate^b, IMS, Q3 of 2007 through Q2 of 2011.

TABLE 2 RADARS System Drug Diversion Program: Total Extended-Release Amphetamine and Oral Methylphenidate Rates

	Rate per		Rate per 100,000
Quarter/Year	1,000 URDD	95% CI	Population	95% CI
Total extended-release oral methylphenidate
Q3/2007	0.022	0.013–0.036	0.015	0.009–0.025
Q4/2007	0.016	0.009–0.029	0.012	0.007–0.022
Q1/2008	0.014	0.008–0.023	0.010	0.006–0.017
Q2/2008	0.024	0.016–0.037	0.016	0.011–0.025
Q3/2008	0.020	0.012–0.034	0.015	0.009–0.024
Q4/2008	0.020	0.012–0.033	0.016	0.010–0.027
Q1/2009	0.039	0.027–0.055	0.033	0.024–0.047
Q2/2009	0.037	0.026–0.053	0.024	0.017–0.035
Q3/2009	0.040	0.028–0.057	0.025	0.018–0.035
Q4/2009	0.018	0.010–0.031	0.014	0.008–0.024
Q1/2010	0.049	0.036–0.068	0.039	0.028–0.054
Q2/2010	0.015	0.008–0.026	0.010	0.005–0.017
Q3/2010	0.026	0.016–0.042	0.019	0.012–0.030
Q4/2010	0.015	0.008–0.028	0.012	0.007–0.022
Q1/2011	0.023	0.015–0.036	0.019	0.012–0.030
Q2/2011	0.045	0.031–0.064	0.031	0.022–0.044
Total extended-release Amphetamines
Q3/2007	0.035	0.023–0.052	0.022	0.015–0.033
Q4/2007	0.028	0.018–0.043	0.019	0.012–0.030
Q1/2008	0.048	0.036–0.063	0.034	0.026–0.045
Q2/2008	0.039	0.028–0.055	0.027	0.019–0.037
Q3/2008	0.049	0.036–0.067	0.038	0.028–0.052
Q4/2008	0.047	0.034–0.066	0.040	0.029–0.055
Q1/2009	0.048	0.035–0.065	0.042	0.031–0.057
Q2/2009	0.037	0.027–0.051	0.031	0.022–0.042
Q3/2009	0.042	0.031–0.057	0.034	0.025–0.046
Q4/2009	0.034	0.024–0.047	0.034	0.024–0.048
Q1/2010	0.062	0.048–0.079	0.065	0.051–0.084
Q2/2010	0.043	0.033–0.057	0.040	0.030–0.052
Q3/2010	0.037	0.026–0.051	0.038	0.027–0.052
Q4/2010	0.033	0.023–0.046	0.037	0.026–0.051
Q1/2011	0.043	0.032–0.056	0.051	0.039–0.067
Q2/2011	0.048	0.037–0.062	0.057	0.044–0.074

FIGURE 2 RADARS System Drug Diversion Program: Total ER amphetamine and total ER oral methylphenidate rates per (a) 100,000 population and (b) per 1,000 URDD, all sites, Q3 of 2007 through Q2 of 2011.

TABLE 3 RADARS System Poison Center Program: Total Extended-Release Amphetamine and Oral Methylphenidate Rates

	Rate per		Rate per 100,000
Quarter/Year	1,000 URDD	95% CI	Population	95% CI
Total extended-release oral methylphenidate:
Q3/2007	0.207	0.183–0.234	0.144	0.128–0.163
Q4/2007	0.225	0.201–0.251	0.170	0.152–0.190
Q1/2008	0.232	0.208–0.258	0.180	0.162–0.200
Q2/2008	0.236	0.212–0.263	0.168	0.151–0.188
Q3/2008	0.225	0.202–0.251	0.157	0.141–0.175
Q4/2008	0.236	0.214–0.260	0.187	0.170–0.207
Q1/2009	0.197	0.177–0.218	0.165	0.148–0.183
Q2/2009	0.228	0.205–0.253	0.160	0.144–0.178
Q3/2009	0.230	0.207–0.256	0.159	0.143–0.177
Q4/2009	0.207	0.186–0.231	0.154	0.138–0.171
Q1/2010	0.215	0.194–0.238	0.169	0.153–0.188
Q2/2010	0.231	0.208–0.256	0.169	0.152–0.187
Q3/2010	0.229	0.206–0.254	0.165	0.149–0.183
Q4/2010	0.211	0.190–0.234	0.166	0.150–0.185
Q1/2011	0.238	0.216–0.262	0.194	0.176–0.213
Q2/2011	0.254	0.230–0.282	0.173	0.156–0.192
Total extended-release Amphetamines:
Q3/2007	0.132	0.112–0.155	0.084	0.072–0.099
Q4/2007	0.143	0.124–0.165	0.101	0.088–0.117
Q1/2008	0.134	0.116–0.155	0.101	0.088–0.117
Q2/2008	0.141	0.123–0.162	0.105	0.091–0.120
Q3/2008	0.149	0.131–0.169	0.115	0.101–0.131
Q4/2008	0.154	0.137–0.174	0.129	0.114–0.145
Q1/2009	0.157	0.140–0.176	0.135	0.120–0.151
Q2/2009	0.166	0.149–0.185	0.150	0.134–0.167
Q3/2009	0.154	0.137–0.173	0.135	0.121–0.152
Q4/2009	0.161	0.144–0.179	0.158	0.142–0.175
Q1/2010	0.157	0.141–0.174	0.162	0.146–0.180
Q2/2010	0.182	0.165–0.201	0.181	0.164–0.200
Q3/2010	0.141	0.126–0.158	0.141	0.126–0.158
Q4/2010	0.182	0.166–0.201	0.197	0.179–0.216
Q1/2011	0.160	0.145–0.177	0.187	0.169–0.206
Q2/2011	0.181	0.165–0.199	0.204	0.186–0.224

FIGURE 3 RADARS System Poison Center Program: Total ER amphetamine and total ER oral methylphenidate rates per (a) 100,000 population and (b) per 1,000 URDD, all sites, Q3 of 2007 through Q2 of 2011.

FIGURE 4 Total ER amphetamines and total ER oral methylphenidate rates per 1,000 URDD, moderate and major medical outcomes associated with intentional exposures, Q3 of 2007 through Q2 of 2011.