Efficacy of Nano Biphasic Calcium Phosphate in the Treatment of Bone Defects

Abstract

The aim of the present study was to investigate the efficacy of nano biphasic calcium phosphate (nanoBCP) bioceramic in the treatment of periodontal osseous defects. Alveolar bone defects were surgically created bilaterally at the buccal aspects of the upper second premolars in four beagle dogs. After root leveling, nanoBCP was randomly filled in the defect and nothing was put into the contralateral defect as controls. Dogs were killed at the 32th week. Histological observations were processed through a light microscopy. The results revealed that a great amount of functional periodontal fissures formed in the defects in the nanoBCP groups while no new bone formed in the control groups at all. In this study, nanoBCP has proven to work well as a biocompatible and bioactive material to promote periodontal regeneration effectively.