ABSTRACT
A chiral mandelic acid (MA) molecularly imprinted microsphere with magnetism was designed in this paper. Firstly, a Fe3O4 core was synthesized by a simple and classical solvot hermal method. Then the SiO2 shell was coated to the surface of Fe3O4 by a improved Stober method. Finally, dimethylaminoethyl methacrylate (DMAEMA) was graft-polymerized onto the surfaces of Fe3O4 @SiO2 microspheres, and the molecular imprinting was conducted with S-MA as template molecule. The results of ultraviolet (UV) spectroscopy detection indicated that the magnetic chiral molecular imprinting had good selectivity for S-Mandelic acid and its enantiomer.
Funding
This work is financially supported by the National Natural Science Foundation of China (21375069, 21574072, 21675091, 21404065), the Natural Science Foundation for Distinguished Young Scientists of Shandong Province (JQ201403), the Taishan Young Scholar Program of Shandong Province (tsqn20161027), the Key Research and Development Project of Shandong Province (2016GGX102028, 2016GGX102039), the Project of Shandong Province Higher Educational Science and Technology Program (J15LC20), the Scientific Research Foundation for the Returned Overseas Chinese Scholars of State Education Ministry (20111568), the People's Livelihood Science and Technology Project of Qingdao (166257nsh), and the Postdoctoral Scientific Research Foundation of Qingdao.