Host-guest interactions of non-steroidal anti-inflammatory drugs on the functionalized dendronized polymeric nanocomposite, Poly(N-tris[((cyano-ethoxy)methyl] methylacrylamide).

ABSTRACT

The use of dendronized polymers (DP), such as Poly(N-tris[((cyano-ethoxy)methyl]methylacrylamide) (PATCN), as carriers models of different non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen (IBU), Ketoprofen (KTP), and Naproxen (NPX), is reported. DSC and TGA measurements demonstrate strong interactions between dendronized polymeric nanocomposites and these drugs. FT-IR, UV-Vis, and AFM measurements confirm that the interactions in the blend give rise to a compatible new material in only one phase. Using the Fukui Theory (FT), the interaction appears to take place through the main amide and its neighborhood. Thus, the drugs' and polymer's functional groups contribute to the strength of the interaction. The functional groups and the sizes of the drugs are the driving force for the interaction with the DP. Finally, MD calculations are carried out through DFT methods to investigate the behavior of the dendronized polymer, showing that different chain behaviors depend on the placement of the lateral chains.

KEYWORDS:

• Poly(N-tris[((cyano-ethoxy)methyl]methylacrylamide) (PATCN)
• Ibuprofen (IBU)
• Ketoprofen (KTP)
• Naproxen (NPX)
• Polymer blends
• Fukui
• Cavities

Acknowledgments

M. Schmidt thanks CONICYT for Doctoral Fellowship Grant 21130406 and FONDECYT Project Grant 1120091. M. Saavedra thanks the project USA N°1498 and N°1555 of the Universidad de Santiago de Chile (USACH). L. Gargallo thanks Universidad de Tarapacá for invaluable help. G. Kortaberría thanks Gobierno Vasco from Grupos Consolidados. D. Radić and A. Leiva thank Fondecyt Grant 1161159 for partial financial help.