A supramolecular approach to the examination of the structures of some anticancer organoamidoplatinum(II) complexes

Abstract

A range of supramolecular interactions revealed on assessment of crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC₆F₄)NCH₂CH₂NEt₂}(py)Cl], 1; [Pt{(p-HC₆F₄)NCH₂CH₂NEt₂}(py)Cl], 2; [Pt{(C₆F₅)NCH₂CH₂NEt₂}(py)I], 3; [Pt{(p-HC₆F₄)NCH₂CH₂NMe₂}Cl(py)], 4; [Pt{(C₆F₅)NCH₂CH₂NMe₂}Cl_0.4I_0.6(py)], 5 is examined. These interactions frequently include the axial positions above and below the coordination planes. Agostic interactions, inter- and intra-molecular H-bonding and other supramolecular interactions of all compounds were explored for a better understanding of solid state structural properties. This propensity to form a range of supramolecular interactions may assist in docking the drugs to DNA prior to coordination of DNA to these compounds.

A range of supramolecular interactions are revealed on assessment of the crystal packing of the previously reported organoamidoplatinum(II) complexes, [Pt{(p-BrC₆F₄)NCH₂CH₂NEt₂}(py)Cl], [Pt{(p-HC₆F₄)NCH₂CH₂NEt₂}(py)Cl], [Pt{(C₆F₅)NCH₂CH₂NEt₂}(py)I], [Pt{(p-HC₆F₄)NCH₂CH₂NMe₂}Cl(py)], [Pt{(C₆F₅)NCH₂CH₂NMe₂}Cl_0.4I_0.6(py)].

Keywords:

• Intermolecular interactions
• crystal packing
• agostic
• hydrogen bonding
• platinum(II) complexes

Acknowledgements

P.C.J., G.B.D. and A.M.B. are grateful to Monash University for support of this work. R.O thanks the Australian Government for funding support in the form of an Australian Post Graduate Award.