β-cyclodextrin mediated synthesis of indole derivatives: reactions of isatins with 2-amino(or 2-thiole)anilines by supramolecular catalysis in water

ABSTRACT

An elegant, mild, and straightforward strategy for the synthesis of indole derivatives have been accomplished by the biomimetic catalysis for the first time in water under neutral conditions. This supramolecular catalyst oriented methodology provides a sustainable and green protocol for the synthesis of 6H-indolo[2,3-b]quinoxalines and 3H-spiro[benzo[d]thiazole-2,3’-indolin]-2’-one by the reaction of isatin derivatives with 1,2-difunctionalized benzene using β-cyclodextrin (β-CD) as a recoverable and reusable supramolecular catalyst.

GRAPHICAL ABSTRACT

KEYWORDS:

• Supramolecular catalyst
• β-cyclodextrin
• chemoselectivity
• indole derivatives
• heterocyclic compounds

Acknowledgments

Km Neha Shivhare gratefully thank to University Grant Commission, New Delhi, India for the award of Junior Research Fellowship and author is also thankful to SAIF, Punjab University Chandigarh for providing all the spectroscopic and analytical data.

Disclosure statement

No potential conflict of interest was reported by the authors.

Supplementary Material

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