Doxorubicin delivery by polymer nanocarrier based on N-methylglucamine resorcinarene

ABSTRACT

Herein we describe a simple method for the synthesis of polymer nanocarrier for the doxorubicin delivery. The nanocarrier consists of N-methyl-glucamine resorcinarenes that are covalently bound to phenylboronic acid. The nanocarrier is stable at normal pH but is hydrolysed at pH below 6. It demonstrates low cytotoxicity and haemolytic activity. Doxorubicin was successfully loaded into the nanocarriers cavity and its release occurs at pH. Flow cytometry data showed that the carrier improves the penetration of doxorubicin into M-Hela cancer cell lines. The encapsulated doxorubicin demonstrates higher cytotoxicity towards the cancer cells.

Graphical Abstract

KEYWORDS:

• Doxorubicin
• drug delivery
• nanocarrier
• resorcinarene

Acknowledgments

This work was supported by the Russian Foundation for Basic Research under Grant 19-03-00429. The authors are grateful to the staff of the Assigned Spectral-Analytical Center of Shared Facilities for Study of Structure, Composition, and Properties of Substances and Materials of Federal Research for their research and assistance in discussing the results.

Disclosure statement

No potential conflict of interest was reported by the authors.

Ethics approval and consent to participate

Blood was collected at the Clinic of the FRC «KazSC RAS» from healthy patients with their personal consent.

Supplementary material

Supplementary material for this article can be accessed here.

Additional information

Funding

This work was supported by the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities and by the Russian Foundation for Basic Research (RFBR) [19-03-00429].